Friday, December 14, 2007

Natural immunity to HIV

Since the outbreak of HIV, there have been the occasional noted case where an individual after repeated exposure to HIV did not acquire the infection. This is more than simply good luck. Researchers have been gathering evidence to explain this percieved natural immunity to HIV. This understanding will drastically improve the accuracy and effectiveness of treatment by individualizing drug regime and therapies. And of course hopefully lead to the developement of a vaccine.
Recent studies have proposed that the basis of HIV immunity is due to our ethnicity and history of disease experienced by our ancestors. These factors effect our genetic code and determine whether we will be susceptible to the HIV infection.
Genetic resistance to HIV infection works in a variety of ways between different ethnic groups. A genetic defect in those with European or Central Asian ancestry provide the most successful resistance to HIV as yet identified. Around 1% of Northern Europeans are virtually immune to HIV with Swedish people being most likely to remain uninfected. These highly HIV resistant individuals all possess a pair of mutated genes (1 per chromosome) that prevent the developement of the CCR5 cellular receptor that the HIV virus uses to infiltrate the cell. This genetric trait msut be inherited from both parents to have the most effect (homozygous). Inheriting the mutated gene from one parent provides some resistance but it is comparatively weaker (heterozygous). 10 -15% of Northern Europeans have this lesser immunity. By using molecular clocks, this genetic mutation dates back to the middle ages.
Other ethnic groups possess lesser HIV resistance due to increased copies of the gene CCL3L1.
Individuals with the greatest number of copies of CCL3L1 (as compared with their ethnic group)
had increased immunity to HIV. Those with the lowest numbers were the most susceptible and became ill approximately 2.5 times faster than others who were also infected. Increased copies of CCL3L1 appear to effect the amount of cytokines released during the inflammatory response. the cytokines attach to cellular receptors and guide the immune cells. The more cytokines that are attached to cellular receptors means less available sites for HIV infiltration. This type of immunity is not nearly as complete as the genetic mutation of CCR5 but is more prevalent in populations.
The genetic mutations that provide HIV resistance originate before its emergence. The question is why would a mutation persist for so long without reason? Many researchers beleive that other diseases, such as the bubonic plague, dysentary, or small pox were the stimulant to maintain a protective gene. This genetic protection would increase the survival of generations versus individual short term.
Although genetic induced HIV resistance is incredibly promising for the developement of a vaccine and impoved therapies, it does not replace the vital protection of safe sex. There is no guarenteed immunity only better odds.

References:

Novembre, J., Galvani, A., Slatkin, & Montgomery. (2005). The genetic spread of CCNR5 ^ 32 HIV-resistant allele. PLoS Biology, Vol. 3 (11), 1954.

Dotinga, R. (2005). Genetic HIV resistance Deciphered. Retrieved December 14, 2007, from
http://www.wired.com/medtech/health/news/2005/01/66198

9 comments:

JULIA FRANLIN said...


So is possible that HIV Disease can be cured because i have been scammed so many times not until i came across this great man dr akhigbe who helped me at first I never believe all this comment and post about him and I was very sick because i have been infected with HIV Disease for the past two year,just last 2months I keep reading the testimony about this man named dr akhigbe they said that the man is so powerful he have cured different type of diseases, I keep monitor the post of some people about this man and I found out that he was real so i decided to give him a trial I contacted him for help and he said he was going to help me get my cure that all i needed to do was to send him money to prepare the medication after which it will be sent to me via dhl service which i did to my greatest surprise the medication was sent to me he gave me instructions on how to use it that after three weeks i should go for check up,after taking the medicine and follow his instruction after three weeks i went back to the hospital for another test, at first i was shocked when the doctor told me that i was negative i ask the doctor to check again and the result was still the same negative that was how i free from HIV Disease at of the shock i decided to come and share my own testimony with you for those who think there is no cure for HIV Disease the cure as finally come' stop doubting and contact dr akhigbe via email drrealakhigbe@gmail.com he will help you out you can also wattssap him via +2348142454860 he is also perfect in curing DIABETICS,HERPES,HIV/AIDS, ;ALS, CANCER HEPATITIES A AND B, believe me that deadly disease is not longer a deadly sentence becauase dr akhigbe has the cure.the godfather of herbalism.

Laurie Hughes said...

I really appreciate DR AKHIGBE,my name is LAURIE HUGHES . I will never stop testifying DR AKHIGBE , Happiness is all i see now I never thought that I will be cured from HIV virus again. DR AKHIGBE did it for me I have been suffering from a deadly disease (HIV) for the past 2 years now, I had spent a lot of money going from one place to another, from churches to churches, hospitals have been my home every day residence. Constant checks up have been my hobby not until this faithful day, I saw a testimony on how DR AKHIGBE helped someone in curing his HIV disease in internet quickly I copied his email which is drrealakhigbe@gmail.com just to give him a test I spoke to him, he asked me to do some certain things which I did, he told me that he is going to provide the herbal cure to me, which he did, then he asked me to go for medical checkup after some days, after using the herbal cure and i did, behold I was free from the deadly disease,till now no HIV in me again he only asked me to post the testimony through the whole world, faithfully am doing it now,all the testimony of DR AKHIGBE is true please BROTHER and SISTER, MOTHER and FATHER he is great, I owe him in return. if you are having a similar problem just email him on drrealakhigbe@gmail.com or you can whatsApp his mobile number on +2348142454860 He can also cure these diseases like HIVand AIDS HERPES,DIABETICES,CANCER, HEPATITIS B ABC, .ETC .please email drrealakhigbe@gmail.com...or whatAPP him ..+2348142454860 he is a real good and honest man.

Luciana Alejandro said...

If you have Herpes in your whole body such as fever blisters, hsv, or roofing shingles you know what it is like to stay with the pain and discomfort that herpes delivers. I don't need to tell you how awesome it would be to find something that works so well that you no longer need to fear about stress or outbreak,Dr Itua herbal medicine cure my herpes in two weeks of taking it.is genuine and natural herbal medicine it has no side effect, The reason I'm writing this is that I promised Dr Itua I will share his herbal work to the world to see Herpes is no more a big deal.also Dr Itua can as well cure the following diseases...HIV,Hsv 1/2,Hepatitis B,Cancer, Diabetes, Men/Woman Infertility, Scoliosis,Fibromyalgia,Fluoroquinolone Toxicity
Syndrome Fibrodysplasia Ossificans Progressiva.Fatal Familial Insomnia Facator V Leiden Mutation , Lottery Spell,Copd, Shingles,Fibroid, Fibromyalgia, Liver/Kidney Inflamotry, Epilepsy, Coeliac disease,Creutzfeldt–Jakob disease,Cerebral Amyloid Angiopathy, Ataxia,Arthritis,Amyotrophic Lateral Sclerosis,Alzheimer's disease,Adrenocortical carcinoma.Asthma,Allergic Asthma. Here His Contact...drituaherbalcenter@gmail.com/Whatsapp Phone.+2348149277976. I paid for his herbal medicine and sent it to me through Courier Service which I pick it urgently and used.

CELESTINO ARTURO said...

But Dr. Itua, Traditional Herbal Practitioner in Africa, Have cured for HIV which is extracted from some rare herbals. It is highly potential to cure AIDS 100% without any residue. Dr Itua herbal medicine has already passed various blogs on how he use his powerful herbals to heal all kind of diseases such as. Herpes, HIV, Diabetes, Hepatitis, Epilepsy, also his herbal boost immune system as well. I'm telling this because he uses his herbal medicine to cure me from hepatitis B and HIV, which i have being living for 9 months now with no side effect. The Herbal Medicine is just as good when drinking it although i have to use rest room after drinking it which I do not really care about because i just want to get the virus out of my body, I will recommend Dr Itua to anyone sick out here to contact Dr Itua with this following information.
Email...drituaherbalcenter@gmail.com
Whatsapp Or Call...+2348149277967.
He might be late to respond because he always busy with patent, but he will surely get back to you with positive response.

Unknown said...

what a greatest surprise to me that i was cured from Hiv/Aids virus by a powerful herbal doctor, it was just like a dream to me i taught that their is no cure for Hiv/Aids because for about six years i spent so much of my money in hospital but no improvement i was confuse in life until a friend of mine introduce me to this herbal doctor i contacted him on email: nativehealthclinic@gmail.com or WhatsApp/Call him at +2348140073965 if their can be any help and he promise to help me, he prepared a herbal medicine for me i followed his instruction after 18 days i went to hospital for test but i was cured it was a greatest surprise to me so i decide to share this testimony. a very big thanks to this herbal doctor who save my life, please if you have this kind of sickness or any disease do not give up you can contact him whatsapp him on +2348140073965..

donald boykins said...

My name is donald boykins , am here to appreciate Dr Akhigbe for using his herbal medicine to cure my Herpes virus. Is about 3 years and 6 months now I have been living with this virus and it has been a serious problem to me, I was so confused cause i have been taking several drugs to be cured but all of my effort was in vain,one morning i was browsing through the internet then i saw several testimonies about Dr. Akhigbe curing people from Herpes virus and immediately i contacted Dr. Akhigbe on his email: drrealakhigbe@gmail.com, i told him about my troubles and he told me that i must be cured, he gave me some instructions and which i rightly followed. so he prepared a herbal medicine and sent it to me which i used for 2 weeks and i was cured everything was like a dream to me and my Herpes virus was totally gone, dr .Akhigbe, God bless you and give you more power and ability for more cures.i dont know if there is any one out there suffering for herpes virus or any of these diseases..DIABETES, CANCER, HIV/AIDS, HERPES HEPATITiES A AND B DISEASES .etc why don't you contact dr.Akhigbe today and be free from your diseases because he is very good and honest Doctor and he is also called the godfather of habalism contact him via email; drrealakhigbe@gmail.com or whatsApp him on +2348142454860

mary loveth said...


Hello everybody,

MY IS LOVETH, I don't just know the reason why some people is finding it difficult to

believe that there is a cure for herpes, I have been suffering from herpes since last

three years with my boyfriend but today I am happy that am cure from it with the herbal

medicine of DR ediale the great healer, I was browsing the internet searching for help

when I came across a testimony shared by someone on how DR ediale cure his herpes I was

so much in need of getting his treatment but after all DR ediale brought a smile to my

face with his herbal medicine. I am so much happy today that we have someone like this

great healer out there, so my people out there kindly contact this great healer on his

email address: edialevincentspellcasterspellcaster@gmail.com please sir keep your good

work cause there are people out there who is in need of your healing medicine.once more

contact, whatsApp number, +1 4132390270

mary loveth said...


Hello everybody,

MY IS LOVETH, I don't just know the reason why some people is finding it difficult to

believe that there is a cure for herpes, I have been suffering from herpes since last

three years with my boyfriend but today I am happy that am cure from it with the herbal

medicine of DR ediale the great healer, I was browsing the internet searching for help

when I came across a testimony shared by someone on how DR ediale cure his herpes I was

so much in need of getting his treatment but after all DR ediale brought a smile to my

face with his herbal medicine. I am so much happy today that we have someone like this

great healer out there, so my people out there kindly contact this great healer on his

email address: edialevincentspellcasterspellcaster@gmail.com please sir keep your good

work cause there are people out there who is in need of your healing medicine.once more

contact, whatsApp number, +1 4132390270

mary loveth said...


Hello everybody,

MY IS LOVETH, I don't just know the reason why some people is finding it difficult to

believe that there is a cure for herpes, I have been suffering from herpes since last

three years with my boyfriend but today I am happy that am cure from it with the herbal

medicine of DR ediale the great healer, I was browsing the internet searching for help

when I came across a testimony shared by someone on how DR ediale cure his herpes I was

so much in need of getting his treatment but after all DR ediale brought a smile to my

face with his herbal medicine. I am so much happy today that we have someone like this

great healer out there, so my people out there kindly contact this great healer on his

email address: edialevincentspellcasterspellcaster@gmail.com please sir keep your good

work cause there are people out there who is in need of your healing medicine.once more

contact, whatsApp number, +1 4132390270